Antimicrobial Activity of Novel Deep Eutectic Solvents

Herein, we utilized several deep eutectic solvents (DES) that were based on hydrogen donors and acceptors for their antibacterial application. These DES tested bactericidal activities against Gram-positive (Streptococcus pyogenes, Bacillus cereus, Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus) Gram-negative (Escherichia coli K1, Klebsiella Pseudomonas aeruginosa, Serratia marcescens) bacteria. Using lactate dehydrogenase assays, evaluated cytopathic effects towards human cells. Results from tests revealed prepared the combination of methyl-trioctylammonium chloride glycerol (DES-4) form fructose (DES-11) at a 2 µL dose showed broad-spectrum behavior had highest activity. Moreover, DES-4 40% 68% activity P. aeruginosa E. respectively. Similarly, DES-11 eliminated 65% 61% K1 Among bacteria, important activity, inhibiting 75% B. cereus 51% S. pneumoniae. Likewise, depicted 70% 50% pneumoniae effects. Finally, limited cytotoxic properties cell lines with exception Methyltrioctylammonium Citric acid (DES-10), which 88% findings suggest depict potent efficacies cause minimal damage to It can be concluded selected in this study could as valuable novel drugs bacterial infections. In future work, mechanisms bactericides cytotoxicity these will investigated.